Empowering regenerative health solutions for ageing and disease
Our capacity to heal is maximal early in life
As we age the capacity of our tissues to regenerate diminishes. This results in loss of function, chronic inflammation, and cancer. Potency for healing is greatest in the stem and developing cells of our primal self when tissues form.
For over twenty-five years, human pluripotent stem cells have provided a gold standard for studying development and disease. These are immortal cells that can give rise to all of the cells in our body. For some time they have been used to make cells for research discovery and to replace those lost to injury or disease.
Our vision is that they also provide the route to identifying the means to boost cell & tissue regeneration for healthy ageing and treatment of disease, via the factors made by primal cells.
Pluripotent stem cells route to our primal self
Identifying regenerative factors from primal cells
Cells and organs which form by the time of our birth originate from primal cells in developing tissues. These divide, migrate and intermingle within germinal layers of cells known as endoderm, mesoderm and ectoderm. These primitive lineages and differentiated cells and tissues that arise from them can be made in culture from pluripotent stem cells.
Mesoderm is the source of mesenchymal stromal cells that form the connective tissue of mature organs. There are many variations of these and their properties differ according to which organ they form in, stage of development, and method of culture in a dish. In our bodies they support more specialised cells in an organ and healing when injured. This is through factors released by them. These can be discovered and synthesized or isolated from the medium cells are cultured in (Figure).
Route from cultured pluripotent stem cells to differentiation of germinal mesodermal lineages and then primal mesenchymal stromal cells before adult cells and tissues form. Variants of these (1.0, 2.0, 3.0, etc) can be made and factors released from them into culture media can be isolated as different fractions (i, ii, iii, iv, etc) and identified.
Primal cell factor formulations with anti-ageing potential
Stroma Therapeutics has innovated methods to specify primal mesenchymal stromal cells from human pluripotent stem cells. Characterisation of genes and proteins expressed and released by these and their activities confirms those found in adult tissue derived cells and still more used to develop tissues. Together these can act on the hallmarks of ageing in novel formulations for healthy ageing and treatment of adult onset disease.
Stroma Therapeutics primal cell factor derived potencies for treatment of ageing and adult-onset disease associated hallmarks.