Regenerative Health From Developing Cells
Our capacity to heal is maximal early in life
In life we lose the capacity to heal as we age. This manifests as chronic inflammation, loss of organ function and cancer. This is brought on by many factors internal and external to our cells that affect their growth and function. Potency for healing is greatest in the cells of our primal self when our tissues are developing.
Phases of potential for cell and tissue (re)-generation and degeneration through the life course and onset of symptoms of ageing.
Pluripotent stem cell route to our primal self
For over twenty-five years, human pluripotent stem cells have provided a gold standard for studying development and disease. These are immortal cells that can give rise to all of the cells in our body. For some time they have been used to make cells for research discovery and to replace those lost to injury or disease. Our vision is that they also provide the means to boost cell & tissue regeneration for healthy ageing via the factors made and released by primal cells.
Tightly packed colonies of human plurioptent stem cells surrounded by spontaneously differentiating cells
Isolating regenerative factors from primal cells
Cells and organs which form by the time of our birth originate from primal cells in developing tissues. These divide, migrate and intermingle within germinal layers of cells known as endoderm, mesoderm and ectoderm. Mesoderm is the source of mesenchymal stromal cells that form the connective tissue of mature organs. There are many variations of these and their properties differ accordomg to which organ they form in, stage of development, and method of culture in a dish. In our bodies they support more specialised cells in an organ and healing when injured. This is through factors released by them These can be isolated from the medium they are cultured in by size or other properties.
Route from cultured pluripotent stem cells to differentiation of germinal mesodermal lineage associated primal mesenchymal stromal cell variants (1.0, 2.0, 3.0, etc) and differt fractions (i, ii, iii, iv, etc) of factors released (secreted) into culture media
Primal cell factor formulations with anti-ageing potential
Stroma Therapeutics has innovated methods to specify primal mesenchymal stromal cells from human pluripotent stem cells. Characterisation of cell- and released protein expression and function substantiates potencies associated with adult tissue derived cells and more associated with their role in developing tissues that can impact on the hallmarks of ageing. These will form the basis of anti-ageing cell and tissue regenerative formulations for novel person and conditioned directed interventions.
Stroma Therapeutics anticipated primal cell factor associated potencies for treatment of ageing hallmarks.